Friday, 27 May 2016, 10 a.m. (sharp), **Prof. Benoit Perthame**, Laboratoire Jacques-Louis Lions, UPMC, Paris, at the conference room of IMATI-CNR in Pavia, will give a lecture titled:

PDE MODELS FOR NEURAL NETWORKS

as part of the Franco - Italian Seminar.

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Abstract.

Neurons exchange informations via discharges, propagated by membrane potential, which trigger firing of the many connected neurons. How to describe large networks of such neurons? What are the properties of these mean-field equations? How can such a network generate a spontaneous activity? Such questions can be tackled using nonlinear integro-differential equations. These are now classically used in the neuroscience community to describe neuronal networks or neural assemblies. Among them, the best known is certainly Wilson-Cowan's equation which describe spiking rates arising in different brain locations.

Another classical model is the integrate-and-fire equation that describes neurons through their voltage using a particular type of Fokker-Planck equations. Several mathematical results will be presented concerning existence, blow-up, convergence to steady state, for the excitatory and inhibitory neurons, with or without refractory states. Conditions for the transition to spontaneous activity (periodic solutions) will be discussed.

One can also describe directly the spike time distribution which seems to encode more directly the neuronal information. This leads to a structured population equation that describes at time t the probability to find a neuron with time s elapsed since its last discharge. Here, we can show that small or large connectivity leads to desynchronization. For intermediate regimes, sustained periodic activity occurs. A common mathematical tool is the use of the relative entropy method.

This talk is based on works with K. Pakdaman and D. Salort, M. Caceres, J. A. Carrillo and D. Smets.